High levels of cholesterol in the blood can lead to heart disease, which is the number-one cause of death in the United States. In this podcast, Michael Miller, M.D., explains what cholesterol is, where it comes from, and its connection with heart disease.

Among the topics: the differences between "good" and "bad" cholesterol and the role of diet, exercise and medications in lowering cholesterol. Dr. Miller is director of preventive cardiology at the University of Maryland Medical Center, and a professor of medicine and epidemiology at the University of Maryland School of Medicine.

Speaking with Bill Seiler, he also explains what criteria physicians use to recommend medications in order to control cholesterol.