Osteoporosis medications - bisphosphonate derivatives
Osteoporosis (bone loss) is the primary disease associated with long-term calcium deficiency. Osteoporosis may be associated with bone pain and spinal deformity. Depleted levels of calcium can also cause muscle cramps, irregular heartbeat, and depression.Phosphorus
Although phosphorus deficiency is rare, chronic low levels are associated with muscle weakness, bone pain, mental confusion, loss of appetite, anemia, increased susceptibility to infection, respiratory difficulties, seizures, and even death.
The information presented here covers some of the nutrients that may be affected when you take certain medications. If you have the signs and symptoms listed, it doesn't always mean you have low levels of these nutrients. Many things affect the level of nutrients, including your medical history, diet, and lifestyle, as well as how long you have been taking the medication. Please talk with your health care provider. He or she can best address your health care needs and determine whether you are at risk for low levels of any nutrients.
Basu N, Reid DM. Bisphosphonate-associated osteonecrosis of the jaw. Menopause Int. 2007;13(2):56-9.
Cashman KD. Diet, nutrition, and bone health. J Nutr. 2007;137(11):2507S-12S.
Jara A, Lee E, Stauber D, Moatamed F, Felsenfeld AJ, Kleeman CR. Phosphate depletion in the rat: effect of bisphosphonates and the calcemic response to PTH. Kidney Int. 1999;55(4):1434-43.
Ondrak KS, Morgan DW. Physical activity, calcium intake and bone health in children and adolescents. Sports Med. 2007;37(7):587-600.
Palacios C. The role of nutrients in bone health, from A to Z. Crit Rev Food Sci Nutr. 2006;46(8):621-8.
Sheweita SA, Khoshhal KI. Calcium metabolism and oxidative stress in bone fractures: role of antioxidants. Curr Drug Metab. 2007;8(5):519-25.
- Last reviewed on 9/21/2014
- Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed HealthCare Network. Also reviewed by the A.D.A.M. Editorial team.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.