Fluconazole (By mouth)


Fluconazole (floo-KON-a-zole)

Prevents and treats fungal infections.

Brand Name(s)


When This Medicine Should Not Be Used

How to Use This Medicine

Liquid, Tablet

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Oral liquid: Shake well just before each use. Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the oral liquid in the refrigerator or at room temperature and use it within 14 days. Do not freeze.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with astemizole, cisapride, erythromycin, pimozide, quinidine, or terfenadine.
  • Some foods and medicines can affect how fluconazole works. Tell your doctor if you are using cimetidine, midazolam, prednisone, rifabutin, rifampin, theophylline, tofacitinib, triazolam, vitamin A supplements, or voriconazole. Also tell your doctor if you are using any of the following:
    • A blood thinner (such as warfarin)
    • A diuretic or "water pill" (such as hydrochlorothiazide), or blood pressure medicine (such as amlodipine, felodipine, isradipine, losartan, nifedipine)
    • Birth control pills
    • Cancer medicine (cyclophosphamide, vinblastine, vincristine)
    • Diabetes medicine that you take by mouth (glipizide, glyburide, tolbutamide)
    • Medicine to lower cholesterol (atorvastatin, fluvastatin, simvastatin)
    • Medicine to treat depression (amitriptyline, nortriptyline)
    • Medicine to treat HIV/AIDS (saquinavir, zidovudine)
    • Medicine to treat malaria (halofantrine)
    • Medicine to treat seizures (carbamazepine, phenytoin)
    • Medicine that weakens the immune system (cyclosporine, sirolimus, tacrolimus)
    • Narcotic pain medicine (alfentanil, fentanyl, methadone)
    • Pain or arthritis medicine (aspirin, celecoxib, diclofenac, ibuprofen, naproxen)

Warnings While Using This Medicine

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, heart disease, heart rhythm problems, cancer, or HIV/AIDS.
  • This medicine may cause the following problems:
    • Liver problems
    • Serious skin reactions
    • Changes in heart rhythm, such as a condition called QT prolongation
  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fast, pounding, or uneven heartbeat
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Mild nausea, vomiting, stomach pain, or diarrhea

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 1/27/2017

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