Paliperidone (By mouth)

Introduction

Paliperidone (pal-ee-PER-i-done)

Treats schizophrenia and schizoaffective disorder.

Brand Name(s)

Invega

When This Medicine Should Not Be Used

How to Use This Medicine

Long Acting Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it. Swallow the tablet with a liquid.
  • If you take the extended-release tablet, part of the tablet may pass into your stools. This is normal and is nothing to worry about.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how paliperidone works. Tell your doctor if you are using any of the following:
    • Carbamazepine, divalproex sodium, levodopa, paroxetine
    • An antibiotic medicine (including, gatifloxacin, moxifloxacin)
    • Blood pressure medicine
    • Medicine for heart rhythm problems (including, amiodarone, procainamide, quinidine, sotalol)
    • Medicine for mental illness (including, chlorpromazine, thioridazine)
  • Do not drink alcohol while you are using this medicine.
  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, stomach or bowel blockage, Reye syndrome, brain tumor, Parkinson disease, dementia, trouble swallowing, or a history of breast cancer, seizures, or neuroleptic malignant syndrome. Tell your doctor if you have blood vessel or heart problems, heart failure, heart rhythm problems, low blood pressure, or a history of a heart attack or stroke.
  • This medicine may cause the following problems:
    • Increased risk of stroke
    • Neuroleptic malignant syndrome (a nerve disorder that could be life-threatening)
    • QT prolongation (heart rhythm problem)
    • Tardive dyskinesia (a muscle disorder that could become permanent)
    • High blood sugar or high cholesterol levels
    • Increased levels of prolactin hormone
    • Unusual mood or behavior
  • This medicine may make you dizzy or drowsy, or may cause trouble with thinking or controlling body movements, which may lead to falls, fractures or other injuries. Do not drive or do anything that could be dangerous until you know how this medicine affects you. You may also feel lightheaded when suddenly getting up from a lying or sitting position, so stand up slowly.
  • This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.
  • This medicine may change how your body regulates temperature. Avoid activities that could cause you to become very cold, hot, or dehydrated.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chills, cough, sore throat, body aches
  • Fast, slow, pounding, or uneven heartbeat
  • Fever, confusion, sweating, muscle stiffness
  • Jerky muscle movements you cannot control (often in your face, tongue, or jaw)
  • Lightheadedness, dizziness, fainting
  • Mood or behavioral changes or thoughts of hurting yourself or others
  • Painful, prolonged erection of the penis (in males)
  • Seizures
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Anxiety, restlessness
  • Headache
  • Nausea, vomiting, stomach pain
  • Sleepiness or unusual drowsiness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 10/4/2017

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