Paliperidone (By injection)
Paliperidone Palmitate (pal-ee-PER-i-done PAL-mi-tate)
Treats schizophrenia and schizoaffective disorder.
Invega Sustenna, Invega Trinza
When This Medicine Should Not Be Used
How to Use This Medicine
- Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
- A nurse or other health provider will give you this medicine.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Missed dose: You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some foods and medicines can affect how paliperidone works. Tell your doctor if you are using any of the following:
- Carbamazepine, levodopa, paroxetine, rifampin, St John's wort
- An antibiotic medicine (including, gatifloxacin, moxifloxacin)
- Blood pressure medicine
- Medicine for heart rhythm problems (including, amiodarone, procainamide, quinidine, sotalol)
- Medicine for mental illness (including, chlorpromazine, thioridazine)
- Do not drink alcohol while you are using this medicine.
- Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.
Warnings While Using This Medicine
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, Parkinson disease, dementia, trouble swallowing, or a history of breast cancer, seizures, or neuroleptic malignant syndrome. Tell your doctor if you have blood vessel or heart problems, low blood pressure, heart failure, heart rhythm problems, or a history of a heart attack or stroke.
- This medicine may cause the following:
- Increased risk of stroke
- Neuroleptic malignant syndrome (a nerve disorder that could be life-threatening)
- QT prolongation (heart rhythm problem)
- Tardive dyskinesia (a muscle disorder that could become permanent)
- High blood sugar or high cholesterol levels
- Increased levels of prolactin hormone
- This medicine may make you dizzy or drowsy, or may cause trouble with thinking or controlling body movements, which may lead to falls, fractures or other injuries. Do not drive or do anything that could be dangerous until you know how this medicine affects you. You may also feel lightheaded when suddenly getting up from a lying or sitting position, so stand up slowly.
- This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.
- This medicine may change how your body regulates temperature. Avoid activities that could cause you to become very cold, hot, or dehydrated.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chills, cough, sore throat, body aches
- Fast, slow, pounding, or uneven heartbeat
- Fever, confusion, sweating, muscle stiffness
- Jerky muscle movements you cannot control (often in the face, tongue, or jaw)
- Lightheadedness, dizziness, or fainting
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Anxiety, restlessness
- Pain, itching, burning, swelling, or a lump under your skin where the shot was given
- Sleepiness or unusual drowsiness
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last reviewed on 10/4/2017
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.