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Maryland Heart Center

Research Highlights

Selected References for William Stanley, Ph.D., Director, Cardiac Energy Metabolism Program

  1. Chandler, M.P., W.C. Stanley, H. Morita, G. Suzuki, B. Blackburn, A. Wolff, H.N. Sabbah. Acute treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure. Circ. Res. 91: 278-280, 2002.

  2. Chandler, M.P., PN Chavez, T.A. McElfresh, H. Huang, and W.C. Stanley. Partial inhibition of fatty acid oxidation increases regional contractile power and efficiency during demand-induced ischemia. Cardiovasc Res 59:143-151, 2003.

  3. Dyck JRB, Cheng JF, Stanley WC, Barr R, Chandler MP, Brown S, Wallace D, Arrhenius T, Harmon C, Yang G, Nadzan AM, Lopaschuk GD. Malonyl CoA decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ. Res. 94:e78-e84, 2004.

  4. Chandler MP, Kerner J, Huang H, Martini WZ, Reszko A, Brunengraber H, Hoppel CL, Sabbah HN, Stanley WC. Moderate severity heart failure does not involve a down-regulation of myocardial fatty acid oxidation. Am J Physiol 287:H1538-1543, 2004.

  5. Sharma N, I Okere, DZ Brunengraber, T McElfresh, KL King, JP Sterk, H Huang, MP Chandler, WC Stanley. Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac energy expenditure. J Physiol (London) 562:593–603, 2005.

  6. Lei B; Matsuo K, Labinskyy V, Sharma N, Chandler MP, Ahn A, Hintz TH, Stanley WC, Recchia FA. Exogenous nitric oxide reduces glucose transporter translocation and lactate production in ischemic myocardium in vivo. Proc Nat Acad Sci 102:6966-6971, 2005.

  7. Stanley WC, Morgan EE, Huang H, McElfresh TA, Okere I, Sterk JP, Chandler MP, Cheng JF, Dyck JRB, Lopaschuk GD. Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia. Am J Physiol, 289: H2304-H2309, 2005.

  8. Zhou L, Stanley WC, Saidel GM, Yu X, and Cabrera ME. Regulation of lactate production at the onset of ischemia is independent of mitochondrial NADH/NAD+: insights from in silico studies. J Physiol (London) 569:925–937, 2005.

  9. Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol. Rev 85:1093-1129, 2005.

  10. Okere IC, Chandler MP, McElfresh TA, Rennison JH, Sharov V, Sabbah HN, Tserng KY, Hoit BD, Ernsberger P, Young ME, Stanley WC. Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin. Am J Physiol Heart Circ Physiol 291:H38-44, 2006.

  11. Zhou L, Cabrera ME, Okere IC, Sharma N, Stanley WC. Regulation of myocardial substrate metabolism during increased energy expenditure: insights from computational studies. Am J Physiol Heart Circ Physiol 291:1036-1046, 2006.

  12. Sharma N, Okere IC, Duda MK, Johnson J, Yuan C, McElfresh TA, Chandler MP, Ernsberger PR, Hoit BD, Stanley WC. High fructose diet increases mortality in hypertensive rats compared to a high fat or complex carbohydrate diet. Am J Hypertension 2006 (in press).

  13. Okere IC, Young ME, McElfresh TA, Chess DJ, Sharov V, Sabbah HN, Hoit BD, Ernsberger P, Chandler MP, Stanley WC. A low carbohydrate/high fat diet attenuates ventricular hypertrophy, remodeling, and switching of gene expression with hypertension. Hypertension 2006 (in press).

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