Joslin Diabetes Center

Official Title:

Genetics of Pancreatic Function in the Development of Diabetes

Purpose:

Find out whether some people are more likely to get diabetes than others by studying their genes.

Investigator(s):

Kristi Silver, M.D.

Requirements:

Sampling of blood sample (fingerstick) to determine genotype
Between ages of 18 & 45 years
Generally good health

Participation:

The first part of the study involves one brief (15 minute) visit to collect a blood sample for genotyping. The second part of the study involves 2 separate visits, the first lasting approximately 4 hours and the second lasting approximately 6 hours. During the second part of the study, volunteers will undergo a test for diabetes (2 hour test), measurements of body fat via X-ray, and measurements of insulin production by the pancreas. Financial compensation provided for time.

Contact:

Dr. Silver 410-706-1628

Official Title:

Pharmacogenetics of Pro12Ala PPAR-gamma-2

Purpose:

To study individual response to glucose-lowering medicine in people who have pre-diabetes development.

Investigator(s):

Alan Shuldiner, M.D.

Requirements:

Sampling of blood sample (fingerstick) to determine genotype

Between ages of 35 & 70 years

Participation:

Three-month treatment with diabetes medicine (avandia), followed by 12-week weight-loss program. Four to six visits in initial three-month treatment. Weekly visits for weight-loss program. Financial compensation provided for time.

Contact:

Soren Snitker MD, PhD 410-706-1511

Official Title:

Genetics of Diabetes and Obesity

Purpose:

Study genes that may contribute to the development of diabetes and obesity.

Investigator(s):

Alan Shuldiner, M.D., Kristi Silver, M.D.

Requirements:

Participants can include ANYONE (those with diabetes, those without diabetes, those who are overweight, those who do not have weight problems).

Participation:

One brief visit to collect blood sample and complete a short questionnaire. Through participation in this study, a person may qualify for other studies that research particular genotypes.

Contact:

Dr. Silver 410-706-1628

Official Title:

Bypass Angioplasty Revascularization Investigation 2 Diabetes

Purpose:

Study cardiovascular disease in type 2 diabetes. Aggressive management of identified cardiovascular disease and diabetes by a collaborative team consisting of cardiologists, endocrinologists, nurses, nutritionists, and exercise physiologist.

Investigator(s):

Tom Donner, M.D., Liz Streeten, M.D.

Requirements:

A positive stress test or angina symptoms that require evaluation by cardiac catheterization.

Participation:

5 year study. Some medications (FDA approved) available thru the study. Glucose monitor and strips now available.

Contact:

Dr. Donner at 410-328-6542 or Dana, RN, at 410-328-1045.

Official Title:

Epidemiology of Diabetes Interventions and Complications

Purpose:

To study diabetes complications in people with Type 1 diabetes who participated in the Diabetes Complications and Control Trial to assess long term effects of intensive management.

Investigator(s):

Matthew Hebdon, M.D., Debra Counts, M.D., Thomas Donner, M.D.

Requirements:

Participant in DCCT

Contact:

Sherry 410-328-3411

Official Title:

TrialNet

Purpose:

To screen siblings, parents, and children of people with Type 1 diabetes for diabetes risk, and to develop methods to prevent Type 1 diabetes.

Investigator(s):

Debra Counts, M.D.

Requirements:

Age 4 - 45
Relative of someone with Type 1 diabetes

Contact:

Mary 410-328-5419

Official Title:

Preservation of insulin-producing cells in children with new onset Type 1 diabetes.

Purpose:

To test a special diet in children newly diagnosed with Type 1 diabetes to see if the remaining insulin-producing ability can be preserved.

Investigator(s):

Debra Counts, M.D.

Requirements:

Age < 18 years
Type 1 Diabetes diagnosed < 6 weeks ago

Contact:

Mary 410-328-5419 or Dr. Counts 410-328-3412