Hepatitis
Description
An in-depth report on the causes, diagnosis, treatment, and prevention of hepatitis.
Highlights
Drug Approval
Peginterferon alfa-2a (Pegasys) was approved in 2005 for treatment of chronic hepatitis B. The injectable drug was previously approved for chronic hepatitis C.
Drug Warning
Patients with hepatitis A or B should not take acetaminophen (Tylenol), according to research presented at the 2006 Digestive Disease Week conference. The nonprescription pain reliever may increase the risk of liver failure.
Herbal Remedies
Milk thistle does not reduce deaths from hepatitis B or C liver diseases, according to a
Cochrane Database
review.
Hepatitis A
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The U.S. Centers for Disease Control now recommends hepatitis A vaccination for all children ages 1 year or older.
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Routine vaccination of children has dramatically reduced hepatitis A outbreaks.
Hepatitis B
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Vaccinating newborn babies of mothers infected with hepatitis B prevents the virus from being passed from mother to child.
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Patients who are resistant to lamivudine (Epivir) can benefit from switching to entecavir (Baraclude). The drugs are similar, but entecavir appears to have less risk of drug resistance.
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Adefovir (Hepsera) must be taken on a long-term basis to prevent the hepatitis B virus from replicating. When patients stop taking the drug too soon, the virus may return.
Hepatitis C
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Illegal intravenous drug use is the main risk factor for hepatitis C. A 2006 study found that nearly half of all patients with hepatitis C have a history of injecting drugs.
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The longer a person has chronic hepatitis C, the greater their risk of developing cirrhosis or liver disease, indicates a 2005 study.
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A combination of interferon and ribavirin works better than interferon alone for treating hepatitis C but the combination can cause side effects. Patients with certain types of hepatitis C may do well with a shorter course of treatment.
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Review Date: 8/17/2006
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Reviewed By: Harvey Simon, MD, Editor-in-Chief, In-Depth Reports; Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital
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