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Coronary artery disease

Description

An in-depth report on the causes, diagnosis, treatment, and prevention of CAD.


Alternative Names

Angina; Atherosclerosis; Heart disease


Prognosis

In the U.S., coronary artery disease is the leading killer of both men and women. In 2003, nearly 500,000 people died because of CAD. On the positive side, heart attack mortality rates have been declining. Half of men and 63% of women who die of heart disease do not have angina or other warning symptoms prior to their fatal attacks. Although at this time no tests can reliably predict whether a heart attack will occur, experts estimate that up to 30% of fatal attacks and many follow-up surgeries could be avoided with healthy lifestyle changes and by sticking to medical treatments. Two-thirds of patients who have suffered a first heart attack, however, do not take the necessary steps to prevent another.

Determining the Degree of Severity

The following syndromes suggest different degrees of severity among patients with heart disease.

Stable Angina. This condition can usually be managed with lifestyle measures and medications, such as low-dose aspirin. The more severe the angina, however, the greater the chance for progressing to a more serious condition.

Acute Coronary Syndromes (ACS).  ACS  includes severe and sudden heart conditions that require aggressive treatment but have not developed into a full-blown heart attack. ACS refers to either unstable angina or NSTEMI (non ST-segment elevation myocardial infarction). NSTEMI is also known as non Q-wave myocardial infarction.

Angina
Angina is a specific type of pain in the chest caused by inadequate blood flow through the blood vessels (coronary vessels) of the heart muscle (myocardium).

Most discussions of the treatment of unstable angina now refer to acute coronary syndrome. Doctors use the presence of a number of factors to help predict which ACS patients are most at risk for developing a heart attack.

First, patients are categorized by whether they have a history of heart disease or risk factors for heart disease (such as diabetes, high blood pressure, peripheral artery disease), or other complicating conditions (such as lung disease, heart failure). The doctor also evaluates the severity of the angina. Other factors that pose a high risk for ACS include:

Heart Attack. A full-blown heart attack occurs with severe damage to the heart, which blocks oxygen.

Indications of a Heart Attack

ANYONE WHO BELIEVES THEY ARE HAVING A HEART ATTACK SHOULD IMMEDIATELY CALL THE EMERGENCY MEDICAL SYSTEM (911 IN THE UNITED STATES).

People with known heart disease and any unusual chest pain or other symptoms of heart attack that do not clear up with medications should go to the hospital. The degree of pain and the specific symptoms before a heart attack vary greatly among individuals. Symptoms can be abrupt, gradual, or intermittent.

Heart Attack Symptoms

Chest Pain. People with heart disease or risk factors should be concerned about any chest pain, usually precipitated by exercise or stress, that interrupts normal activities and does not clear up after resting or taking angina medications. Chest symptoms might be experienced as follows:

  • Pain is typically felt as a crushing weight against the chest, accompanied by profuse sweating. The pain may radiate to the left shoulder and arm, the neck or jaw, and even infrequently to the right arm. The arm may be tingling or numb.
  • Some people may only have a tingling sensation or a sense of fullness, squeezing, or pressure in the chest.
  • In some patients with a history of heart disease, chest pain is mild. Such patients may have experienced unexplained fatigue, depression, and ill health within a month of a heart attack. Although chest pain is the classic symptom, it occurs in only about half of patients with a heart attack.

Other Common Symptoms.

  • Nausea, vomiting, and cold sweats
  • A feeling of indigestion or heartburn
  • Fainting
  • A great fear of impending death, a phenomena known as angor animi

Atypical Symptoms. Some studies suggest that nearly half of patients with heart attack do not have chest pain as the primary symptom. Common atypical symptoms of a heart attack include:

  • Shortness of breath
  • Cardiac arrest
  • Dizziness, weakness, and fainting
  • Abdominal pain

Patients most likely to have atypical symptoms are women and the very elderly (although they can certainly have classic heart attack symptoms as well).

  • In one study, 52% of elderly people with acute coronary syndrome had atypical symptoms that included shortness of breath, nausea, profuse sweating, pain in the arms, and fainting. Such symptoms were more likely to occur in people with personal or family history of heart disease.
  • Before a heart attack, women are more likely than men to be nauseous and experience pain high in the abdomen or chest. Their first symptom may be extreme fatigue after physical activity rather than chest pain. Chest pain in women is also more likely to be caused by non-heart problems than in men.

Symptoms That Are Less Likely to Indicate a Heart Attack. The following symptoms are less likely to be due to a heart attack:

  • Sharp pain brought on by lung movements or coughing
  • Pain that is mainly or only in the middle or lower abdomen
  • Pain that can be pinpointed with the top of one finger
  • Pain that can be reproduced by moving or pressing on the chest wall or arms
  • Pain that is constant and lasts for hours (although no one should wait hours if they suspect they are having a heart attack)
  • Pain that is very brief and lasts for a few seconds
  • Pain that spreads to the legs

However, the presence of these symptoms does not always rule out a serious heart event.

Ruling Out Other Causes

Chest pain is a very common symptom in the emergency room, but heart problems account for only 10 - 33% of all episodes.

The most common causes of chest pain are muscular and bone problems. Problems affecting the ribs and chest muscles include injured muscles, fractures, arthritis, spasms, and infections.

Other causes of chest pain include:

  • Anxiety attacks
  • Gastrointestinal disorders (gallstone attacks, peptic ulcer disease, hiatal hernia, heartburn)
  • Asthma
  • Spasm in the coronary artery
  • Abnormalities of the heart muscle
  • Rupture of the aorta
  • Collapsed lung
  • Acute inflammation of the heart
  • Blood clot in the lung
  • High thyroid levels (hyperthyroidism)
  • Anemia
  • Vasculitis (a group of disorders that cause inflammation of the blood vessels)
  • Exposure to high altitudes (rare)

What to Do When Symptoms Occur

Individuals who experience symptoms of a heart attack should take the following actions:

  • For angina patients, take one nitroglycerin dose either as an under-the-tongue tablet or in spray form at the onset of symptoms. Take another dose every 5 minutes up to three doses or when the pain is relieved, whichever comes first.
  • Call 911 or the local emergency number. This should be the first action taken if angina patients continue to experience chest pain after taking the full three doses of nitroglycerin. However, that only 20% of heart attacks occur in patients with long-standing angina. Therefore, anyone who has heart disease or risk factors for it and experiences heart attack symptoms should contact emergency services.
  • The patient should chew an aspirin (250 to 500 mg) and be sure that emergency health providers are informed of this so an additional dose is not given.
  • Patients with chest pain should go immediately to the nearest emergency room, preferably traveling by ambulance. They should not drive themselves.


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