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Osteoporosis - Complications

Description

An in-depth report on the causes, diagnosis, treatment, and prevention of osteoporosis.

Complications:

Bone density loss from osteoporosis is a major cause of disability and death in the elderly, mostly due to subsequent fractures. The lifetime risk of spinal fracture in women is about one in three, and that for hip fracture is one in six. Women at highest risk for fractures are those with low bone density plus a history of fractures, particularly nonviolent fractures.


Osteoporosis
Click the icon to see an animation about osteoporosis.

Osteoporosis causes more than 1.5 million fractures annually. About 50% of women and 25% of men over age 50 will suffer an osteoporosis-related fracture during their lifetime. Each year, there are about 700,000 spinal fractures, 300,000 hip fractures, 250,000 broken wrists and more than 300,000 fractures of other bones. About 80% of these fractures occur after relatively minor falls or accidents.



Click the icon to see an image of a compression fracture.

Click the icon to see an image of a hip fracture.

Unfortunately, studies continue to report inadequate treatment after a fracture. Few patients with sustained fractures are tested or treated for osteoporosis.

Risk Factors for Fracture and Falling. In addition to low bone density, falling is the primary risk factor for fractures. Additional risk factors for fracture are those that increase the risk for falling. They include:

  • Having chronic medical problems (emphysema, heart disease, stroke, arthritis, and depression), with the risk increasing with multiple health problems
  • Taking multiple medications (especially tranquilizers and antidepressants)
  • Poor physical function, importantly slow gait and reduced muscle strength. Inactivity that results in weak thigh muscles and poor balance particularly puts any older person at risk for fracture and particularly those with low bone density.
  • Poor concentration or mental impairment
  • Impaired vision
  • Hazardous environment (such as the presence of throw rugs in the house)

Mortality after Fracture

Hip fractures can increase the risk of death in both men and women. Complications of hip fractures include hospital-acquired infections and blood clots in the lungs.

Resources

References

Ebeling PR. Clinical practice. Osteoporosis in men. N Engl J Med. 2008; 358(14): 1474-82.

Greenspan SL, Bone HG, Ettinger MP, Hanley DA, Lindsay R, Zanchetta JR, et al. Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: a randomized trial. Ann Intern Med. 2007;146(5): 326-39.

Greenspan SL, Nelson JB, Trump DL and Resnick NM. Effect of once-weekly oral alendronate on bone loss in men receiving androgen deprivation therapy for prostate cancer: a randomized trial. Ann Intern Med. 2007;146(6): 416-24.

Heckbert SR, Li G, Cummings SR, Smith NL, Psaty BM. Use of alendronate and risk of incident atrial fibrillation in women. Arch Intern Med. 2008;168(8):826-31.

Kothawala P, Badamgarav E, Ryu S, Miller RM and Halbert RJ. Systematic review and meta-analysis of real-world adherence to drug therapy for osteoporosis. Mayo Clin Proc. 2007;82(12): 1493-501.

MacLean C, Newberry S, Maglione M, McMahon M, Ranganath V, Suttorp M, et al. Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. Ann Intern Med. 2008;148(3): 197-213.

National Osteoporosis Foundation. Clinician's Guide to Prevention and Treatment of Osteoporosis -- 2008. Washington, DC.

Qaseem A, Snow V, Shekelle P, Hopkins R Jr., Forciea MA and Owens DK. Pharmacologic treatment of low bone density or osteoporosis to prevent fractures: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2008;149(6): 404-15.

Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007 Aug 25;370(9588):657-66.

  • Reviewed last on: 11/18/2008
  • Harvey Simon, MD, Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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