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Lyme disease and related tick-borne infections - Highlights

Description

An in-depth report on the causes, diagnosis, treatment, and prevention of Lyme disease.

Alternative Names

Babesiosis; Human granulocytic anaplasmosis (HGA)

Highlights:

Causes

Lyme disease is caused by the bacterium Borrelia (B.) burgdorferi, which is transmitted through the bite of a deer tick. Either nymph or adult ticks can transmit B. Burgdorferi.

Risk Factors

  • Anyone exposed to deer ticks is at risk for Lyme disease. Deer ticks thrive in grassy areas that have low sunlight and high humidity.
  • Nymph ticks are more active during the summer months, and their small size makes them more difficult to spot than adult ticks. Consequently, the risk for acquiring Lyme disease tends to be higher during the summer than the spring or fall. Risk is lowest during, winter when ticks become inactive.

Prevention

  • Avoid tick-infested areas such as tall grass, woods, and bushes.
  • If walking or hiking through these areas, wear long pants and long sleeves. Light-colored clothes will make it easier to spot ticks.
  • Use a tick repellant (DEET, picardin) on your exposed skin and clothes. Spray clothes with permethrin (but NOT the skin).
  • After you return home, do a tick check. Removing infected ticks within 48 hours of attachment significantly reduces the risk of developing Lyme disease.

Symptoms

  • A bull's eye rash, called erythema migrans, is the most definitive sign of Lyme disease infection. This rash usually develops 1 - 2 weeks after the tick bite.
  • Other symptoms, such as joint pains, fever, chills, and fatigue, may accompany the rash.
  • If Lyme disease is not treated, more severe symptoms and complications can occur. These include arthritis, neurologic symptoms, and heart problems.

Treatment

Most cases of Lyme disease can be prevented or cured with prompt antibiotic treatment following a deer tick bite. If a preventive antibiotic is needed, a single dose of doxycycline may suffice. To treat active disease, antibiotics are usually given for 2 - 4 weeks. Current guidelines do not recommend long-term antibiotic treatment for any stage or complication of Lyme disease.

Resources

References

Bakken JS, Dumler S. Human granulocytic anaplasmosis. Infect Dis Clin North Am. 2008 Sep;22(3):433-48, viii.

Bratton RL, Whiteside JW, Hovan MJ, Engle RL, Edwards FD. Diagnosis and treatment of Lyme disease. Mayo Clin Proc. 2008 May;83(5):566-71.

Centers for Disease Control and Prevention. Lyme disease -- United States, 2003-2005. MMWR Morb Mortal Wkly Rep. 2007 Jun 15;56(23):573-6.

Clark RP, Hu LT. Prevention of lyme disease and other tick-borne infections. Infect Dis Clin North Am. 2008 Sep;22(3):381-96, vii.

Feder HM Jr, Johnson BJ, O'Connell S, Shapiro ED, Steere AC, Wormser GP; Ad Hoc International Lyme Disease Group. A critical appraisal of "chronic Lyme disease." N Engl J Med. 2007 Oct 4;357(14):1422-30.

Halperin JJ, Shapiro ED, Logigian E, Belman AL, Dotevall L, Wormser GP, et al. Practice parameter: treatment of nervous system Lyme disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2007 Jul 3;69(1):91-102.

Vannier E, Gewurz BE, Krause PJ. Human babesiosis. Infect Dis Clin North Am. 2008 Sep;22(3):469-88, viii-ix.

Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, et al. The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2006 Nov 1;43(9):1089-134.

  • Reviewed last on: 2/11/2009
  • Harvey Simon, MD, Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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