Services at the UM Medical Center
See a complete list of Specialty Services and Departments at UMMC.Asthma in adults
Description
An in-depth report on how asthma is diagnosed, treated, and managed in adults.
Treatment
Treating an Acute Attack in the Hospital. An acute attack may require hospitalization. Laboratory tests, an electrocardiogram (ECG), and a chest x-ray are performed to determine lung function, oxygen levels, and other indications of severity or rule out other causes. Depending on the results, the following treatments may be given:
- Beta2-agonists are the standard therapy. They may be administered with a nebulizer (a device that administers the drug in a fine spray) or given hourly with an inhaler. Studies are suggesting the use of inhaler is equally or possibly more effective than a nebulizer. Intravenous delivery is not recommended in most cases.
- A corticosteroid (commonly called a steroid) given within the first hour helps reduce the need for hospitalization. Steroids are typically administered intravenously or as an injection in adults. Lower doses work as well as higher ones in these situations.
- Intravenous magnesium opens airways and is an important emergency treatment for patients with very severe asthma.
- Oxygen is usually administered, and can be life saving in severe cases.
- In life-threatening situations, the patient may require mechanical ventilation.
- Antibiotics are not useful for asthma attacks if there is no strong evidence of the presence of a bacterial infection. (Viral infections, most often colds and flus, are more likely to trigger an asthma attack. In such cases, antibiotics do not appear to be beneficial and may have adverse effects.)
Discharge and Relapse After Hospitalization. It typically takes 3 - 4 hours to determine if a patient can be safely sent home or if they need to stay in the hospital. Patients are generally discharged under the following circumstances:
- When symptoms are gone or are minimal, and
- The peak expiratory flow rate is 70% or more of the predicted rate
Discharged patients generally take oral corticosteroids for 5 - 7 days. Despite reasonable precautions, about 20% of patients relapse within 2 weeks, although the risk is very low if they keep taking their medication after they leave.
Guidelines for Treating Asthma at Home
Avoiding allergens, following appropriate drug treatments, and home monitoring are key elements in preventing dangerous asthma attacks and hospitalization. A combination of medications is important for both treating and preventing asthma attacks. In addition, good communication between the doctor and patient is a key factor in a successful management program. Written action plans, which instruct individual patients how to properly respond to changes in their unique symptoms, are a very important element in successful self-management of asthma.
Understanding the Difference Between Treating Symptoms and Controlling the Disease
Patients can greatly reduce the frequency and severity of asthma attacks by understanding the difference between coping with asthma attacks and controlling the disease over time. According to a few studies, most patients do not discriminate between medications that provide rapid short-term relief and long-term symptom control.
Medications for asthma fall into two categories:
- Rescue Medication. Medications that open the airways (bronchodilators, or inhalers) are used to quickly relieve any moderate or severe asthma attack. These drugs are usually short-acting beta-adrenergic agonists (beta2-agonists). Other drugs used in special cases include corticosteroids taken by mouth and anticholinergic drugs. None of these drugs have any effect on the disease process itself. They are only useful for treating symptoms.
- Maintenance Medication. Simply coping with asthma symptoms without also controlling the damaging inflammatory response is a common and serious error. For adults and children over age 5 with moderate-to-severe persistent asthma, experts now recommend inhaled corticosteroids and long-acting beta2-agonists.
Patients can greatly reduce the frequency and severity of asthma attacks by understanding the difference between coping with asthma attacks and controlling the disease over time. Unfortunately, many patients do not understand the difference between medications that provide rapid short-term relief and those that are used for long-term symptom control. Many patients with moderate or severe asthma overuse their short-term medications and underuse their corticosteroid medications. The overuse of bronchodilators can have serious consequences; not using steroids can lead to permanent lung damage.
Patients need to understand that asthma symptoms can change quickly over time and that treatment strategies may need to change. In 2005, the two leading U.S. allergy associations published joint guidelines on controlling asthma. The guidelines emphasize that asthma treatment decisions need to be made on an individual basis. It is important that patients have a close relationship with their doctor. The doctor needs to evaluate a patient’s asthma symptoms at each and every visit to determine if there should be any changes in medication.
According to the guidelines, asthma management is classified as either “well-controlled” or “not well-controlled.” Your doctor may need to change some of your medications, or increase or decrease the dosage, depending on whether your asthma is well-controlled or not well-controlled.
These are the signs of well-controlled asthma:
- Asthma symptoms occur twice a week or less
- Rescue bronchodilator medication is used twice a week or less
- Symptoms do not cause nighttime or early morning awakening
- Symptoms do not limit work, school, or exercise activities
- Peak flow meter readings are normal or the patient’s personal best
- Both the doctor and the patient consider the asthma to be well controlled
Administering Inhaled Drugs
Most asthma drugs are inhaled using various forms of inhalers or nebulizers. Inhaled drugs must be used regularly as prescribed and the patient carefully trained in their use in order for them to be effective and safe. The basic devices are the metered-dose inhaler (MDI), breath-actuated inhalers, dry powder inhalers, and nebulizers.
MDIs have used chlorofluorocarbons (CFCs) as their propellants. CFCs are damaging to the environment. CFCs are now being replaced with other propellants (such as hydrofluoroalkane) that are equally effective to CFCs, are environmentally safe, and do not chill the device as CFCs do. Devices that don't use propellants at all are also now available.
Metered-Dose Inhaler. The standard device for administering any asthma medication has been the metered-dose inhaler (MDI). This device, particularly when used with a holding chamber, allows precise doses to be delivered directly to the lungs.
MDI-delivered drugs must be used regularly as prescribed, and the patient carefully trained in their use, for the drugs to be effective and safe. Some patients hold the MDI too close to their mouths, or even inside them. Others may exhale too forcefully before inhalation. The holding chamber, or spacer, allows the patient additional time to inhale the medication, improving delivery. They vary, however, in their ability to deliver medication. Often MDIs continue to deliver propellant after the drug has been used up. Patients should track their medicine and throw the device away when the last dose has been administered.
Breath-Actuated Inhalers. Breath-actuated rotary inhalers (Easi-Breathe and Autohaler) deliver the drug directly to the back of the throat as the user inhales. Their primary advantage over the MDI is their ease of use. They also do not use CFCs as propellants. In comparison studies, patients have been very successful with the breath-actuated inhalers.
Dry Powder Inhalers. Dry powder inhalers (DPIs) deliver a powdered form of beta2 agonists or corticosteroids directly into the lungs. They also do not use CFCs. Such devices include Rotahaler, Spinhaler, Turbohaler, Clickhaler, Easyhaler, Diskhaler, Discus, Twisthaler, Spiros, and others. DPIs are as effective as the older devices, and generally have a better taste and are easier to manage. They may differ among themselves, however, in their ability to deliver drugs into the airways. In one study, for example, the Turbohaler was easier to use than the Diskhaler, achieving better delivery. The Discus is another effective DPI. It has a dose counter and protects against exhalation effects.
Humidity or extreme temperatures can affect these inhalers' performance, so they should not be stored in humid places (bathroom cabinets) or locations subject to high temperatures (glove compartments during summer months).
Dry-powder may cause tooth erosion, and children are advised to rinse their mouths out right after using a DPI and to brush twice a day with a fluoride toothpaste.
Other Hand-Held Inhalers. Respimat delivers a fine-mist spray that is created by forcing the liquid medication through nozzles. It does not use any propellant.
Nebulizers. A nebulizer is a device that administers the drug in a fine spray that the patient breathes in. They are mostly used in hospital settings or when the patient cannot use an inhaler. Nebulizers may be important for delivering newer drugs used in asthma treatment.
Monitoring
People who self-manage their asthma using daily monitoring of peak air flow and adjusting their medications as needed have fewer hospitalizations, fewer unplanned doctors visits, and, generally, a better quality of life than those who rely only on the occasional doctor or emergency room visit to control symptoms. Doctors recommend that patients with even mild asthma monitor their own conditions.
In general, monitoring involves the following steps:
- A peak flow meter is the standard monitoring device for measuring peak expiratory flow rate (PEFR).
- Patients with severe asthma should take PEFR readings two or three times a day. The overall goal should be to achieve less than a 20% (and ideally only 10%) variation in readings between evening and morning rates. For mild to moderate asthma, a single determination each morning usually suffices, but patients should check with their doctors.
- It is important to use the meter at the same times each day and to stand or sit in the same position to keep an accurate record.
- Patients should keep an ongoing record of their peak flow readings to help them detect worsening of their condition.
- They should also record attacks, exposure to any allergens or triggers, and medications taken.
- After about 2 months, patients and doctors can use the recorded data for administering medications effectively and to recognize problems before they become serious.
In general, many people fail to monitor their asthma. Experts believe that, ideally, portable monitors should be available to measure forced expiratory volume (FEV1), a more accurate gauge of lung function, and the results should be electronically transmitted to the doctor.
New monitoring devices are showing promise in accomplishing one or more of these goals, although they are not covered by most insurers. For example, the AirWatch is a handheld digital monitor that measures and displays the rate of airflow and compares it to the rates from previous days. Once a month, or whenever there is a problem, the patient plugs the device into a standard telephone jack, and the daily readings are sent to an automated data center that creates tables and charts for the patient and the doctor.
Medications for Treatment and Prevention of Asthma |
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| Medication Purpose | Drug Class | Generic Name | Brand Names | Administration |
| Quick-Relief Medications (control acute attacks) | Short-Acting Beta-2 Agonists | Albuterol | Proventil, Ventolin, AccuNeb | Inhaler, nebulizer |
| Levalbuterol | Xopenex | Nebulizer | ||
| Metaproterenol | Alupent | Inhaler | ||
| Pirbuterol | MaxAir | Inhaler | ||
| Ipratropium / Albuterol | Combivent | Inhaler | ||
| Anticholinergics | Ipratropium | Atrovent | Inhaler | |
| Tiotropium | Spiriva | Inhaler | ||
| Systemic Corticosteroids | Cortisone | Cortone | Pill | |
| Dexamethasone | Decadron | Pill | ||
| Hydrocortisone | Cortef | Pill | ||
| Methylprednisolone | Medrol | Pill | ||
| Prednisolone | Orapred, Prelone | Syrup | ||
| Prednisone | Various | Pill | ||
| Triamcinolone | Aristocort | Pill | ||
| Long-Term Relief Medications (prevent attacks and control chronic symptoms) | Inhaled Corticosteroids | Beclomethasone | QVAR | Inhaler |
| Budesonide | Pulmicort | Inhaler, nebulizer | ||
| Budesonide / Formoterol | Symbicort | Inhaler | ||
| Flunisolide | AeroBid | Inhaler | ||
| Fluticasone | Flovent | Inhaler | ||
| Fluticasone / Salmeterol | Advair | Inhaler | ||
| Mometasone | Asmanex | Inhaler | ||
| Triamcinolone | Azmacort | Inhaler | ||
| Long-Acting Beta2-Agonists | Formoterol | Foradil | Inhaler | |
| Salmeterol | Serevent | Inhaler | ||
| Anti-inflammatories | Cromolyn | Intal | Nebulizer | |
| Nedocromil | Tilade | Inhaler | ||
| IgE-inhibitor | Omalizumab | Xolair | Injectable | |
| Leukotriene Modifiers | Montelukast | Singulair | Pill | |
| Zafirlukast | Accolate | Pill | ||
| Zileuton | Zyflo | Pill | ||
| Methylxanthine | Theophylline | Uniphyl, Quibron, Theo-24 | Pill, syrup | |
- Review Date: 3/27/2007
- Reviewed By: Harvey Simon, MD, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital.
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