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• Highlights
• Introduction
• Causes
• Risk Factors
• Symptoms
• Complications
• Diagnosis
• Treatment
• Treatment for Cutaneous and Mild SLE
• Treatment for Severe SLE
• Lifestyle Changes
• Resources
• References

Systemic lupus erythematosus

Description

An in-depth report on the causes, diagnosis, treatment, and prevention of lupus.

Alternative Names

Lupus

Treatment

No treatment cures systemic lupus erythematosus, but many therapies can suppress symptoms and relieve discomfort. Treatment of SLE varies depending on the extent and severity of the disease.

Only three drugs are technically FDA-approved for the treatment of lupus:

• Prednisone
• Aspirin
• Hydroxychloroquine

However, none of these are the standard of care. In everyday practice, numerous other, more effective drugs are commonly used. A new surge of interest has spurred numerous clinical studies and the development of many new therapeutic drugs. Genetic research in lupus is progressing very rapidly, and several new drugs are likely to be approved in the near future. There are also different drugs available to treat some of the conditions associated with lupus.

Treating Mild Systemic Lupus Erythematosus

Less intensive treatments may be effective for symptoms of mild lupus. They include:

• Creams and sunblocks for rashes
• Nonsteroidal anti-inflammatory drugs for fever, arthritis, and headache
• Antimalarial drugs for pleurisy, mild kidney involvement, and inflammation of the tissue surrounding the heart

Treating Severe Systemic Lupus Erythematosus

More aggressive treatment is needed if there is serious disease progression, evidenced by the following:

• Hemolytic anemia
• Low platelet count with an accompanying rash (thrombocytopenia purpura)
• Major involvement in the lungs or heart
• Significant kidney damage
• Acute inflammation of the small blood vessels in the extremities or gastrointestinal tract
• Severe central nervous system symptoms

The primary approach to treating severe SLE is to suppress the immune factors, most often first with corticosteroids and other immunosuppressant drugs. Investigative drugs and procedures are also showing promise.

Treating Specific Complications

The major complications of the disease must be treated as separate problems, keeping in mind the specific aspects of SLE. They are discussed in another section.

• Review Date: 1/2/2007
• Reviewed By: Harvey Simon, MD, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital.

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