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Cataracts - Risk Factors

Description

An in-depth report on the causes, diagnosis, treatment, and prevention of cataracts.

Risk Factors:

Aging is the primary risk factor for cataracts, but other factors are also involved.

Age

Nearly everyone who lives long enough will develop cataracts to some extent. Some people develop cataracts during their middle-aged years (40s and 50s), but these cataracts tend to be very small. It is after age 60 that cataracts are most likely to affect vision. Nearly half of people age 75 and older have cataracts.

Gender

Women face a higher risk than men.

Family History

Cataracts tend to run in families.

Race and Ethnicity

African-Americans seem to have nearly twice the risk of developing cataracts than do Caucasians. This difference may be due to other medical illnesses, particularly diabetes. African-Americans are much more likely to become blind from cataracts and glaucoma than Caucasians, mostly due to lack of treatment.

Hispanic Americans are also at increased risk for cataracts. In fact, cataracts are the leading cause of visual impairment among Hispanics.

Diabetes and Other Medical Conditions

People with certain medical conditions, notably diabetes, are at high risk for cataracts, either because of a direct effect of the disease, its treatments, or both.

Diabetes. People with diabetes type 1 or 2 are at very high risk for cataracts and are much more likely to develop them at a younger age. They also have a higher risk for nuclear cataracts than nondiabetics. Cataract development is significantly related to high levels of blood sugar (hyperglycemia), and cataracts in people with diabetes are sometimes referred to as so-called sugar cataracts.

Autoimmune Diseases and Conditions Requiring Steroid Use. Medical conditions requiring high use of corticosteroids (commonly called steroids) pose a particularly high risk. Many of these medical conditions are autoimmune diseases, including rheumatoid arthritis, psoriasis, multiple sclerosis, systemic lupus erythematosus, Behcet's disease, and others.

Eye Conditions. People who are nearsighted (myopia) are at increased risk of developing cataracts. Physical injuries to the eye (such as a hard blow, cut, or puncture) or eye inflammation can also increase risk. Previous intraocular eye surgery increases cataract risk.

Obesity. Obesity may be a risk factor for cataracts

Overexposure to Sunlight

Exposure to even low-level UVB radiation from sunlight increases the risk for cataracts, especially nuclear cataracts. The risk may be highest among those who have significant sun exposure at a young age. People whose jobs expose them to sunlight for prolonged periods are also at increased risk.

Smoking and Alcohol Use

Smoking. Smoking a pack a day of cigarettes may double the risk of developing cataracts. Smokers are at particular risk for cataracts located in the nuclear portion of the lens, which limit vision more severely than cataracts in other sites.

Alcohol. Chronic heavy drinkers are at high risk for a number of eye disorders, including cataracts.

Environmental Factors

Long-term environmental lead exposure may increase the risk of developing cataracts. Gold and copper accumulation may also cause cataracts. Prolonged exposure to ionizing radiation (such as x-rays) can increase cataract risk.

Resources

References

Allen D. Cataract. BMJ Clinical Evidence. Web publication date: 01 April 2007 (based on October 2006 search). Accessed July 1, 2008.

American Academy of Ophthalmology. Cataract in the Adult Eye, Preferred Practice Pattern. San Francisco: American Academy of Ophthalmology, 2006. Accessed July 1, 2008.

Awasthi N, Guo S, Wagner BJ. Posterior capsular opacification: a problem reduced but not yet eradicated. Arch Ophthalmol. 2009 Apr;127(4):555-62.

Bell CM, Hatch WV, Fischer HD, Cernat G, Paterson JM, Gruneir A, et al. Association between tamsulosin and serious ophthalmic adverse events in older men following cataract surgery. JAMA. 2009 May 20;301(19):1991-6

Clinical Trial of Nutritional Supplements and Age-Related Cataract Study Group, Maraini G, Sperduto RD, Ferris F, Clemons TE, Rosmini F, et al. A randomized, double-masked, placebo-controlled clinical trial of multivitamin supplementation for age-related lens opacities. Clinical trial of nutritional supplements and age-related cataract report no. 3. Ophthalmology. 2008 Apr;115(4):599-607.e1.

Fernandez MM, Afshari NA. Nutrition and the prevention of cataracts. Curr Opin Ophthalmol. 2008 Jan;19(1):66-70.

Friedman AH. Tamsulosin and the intraoperative floppy iris syndrome. JAMA. 2009 May 20;301(19):2044-5.

Guercio JR, Martyn LJ. Congenital malformations of the eye and orbit. Otolaryngol Clin North Am. 2007 Feb;40(1):113-40, vii.

Long V, Chen S, Hatt S. Surgical interventions for bilateral congenital cataract. Cochrane Database Syst Rev. 2006 Jul 19;3:CD003171.

Moeller SM, Voland R, Tinker L, Blodi BA, Klein ML, Gehrs KM, et al. Associations between age-related nuclear cataract and lutein and zeaxanthin inthe diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative. Arch Ophthalmol. 2008 Mar;126(3):354-64.

Olitsky SE, Hug D, and Smith LP. Abnormalities of the lens. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. St. Louis, MO: WB Saunders; 2007; chap 627.

Wishart MS, Dagres E. Seven-year follow-up of combined cataract extraction and viscocanalostomy. J Cataract Refract Surg. 2006 Dec;32(12):2043-9.

  • Reviewed last on: 6/23/2009
  • Harvey Simon, MD, Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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