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Non-small cell lung cancer
Description
An in-depth report on the causes, diagnosis, treatment, and prevention of non-small cell lung cancer (NSCLC).
Alternative Names
Lung cancer - non-small cell; NSCLC
Surgical Procedures
Surgery is performed in the following circumstances:
- The surgical removal of an entire lobe or parts of a lung is the primary treatment for eligible patients in early stages of cancer. Recurrence is high after surgery, although the new tumor is often operable.
- Some patients with stage IIIA cancer may also benefit from surgery. The intent at this stage is to extend survival time, rather than cure the disease.
- Surgery is not out of the question in rare cases of metastasis when the cancer appears in a single operable location, such as the brain.
Unfortunately, lung surgery may be too risky for patients with other lung diseases or serious medical conditions, and because lung cancers tend to occur in smokers over 50, such health problems are likely to be present. Long-term survival rates appear to be better in patients treated at hospitals that perform large numbers of lung cancer surgeries, and when surgeries are performed by thoracic surgeons, who specialize in chest procedures.
Standard Surgical Procedures
The type of surgery depends on the amount of lung or other tissue that needs to be removed.
Wedge Resection or Segmentectomy. Wedge resection and segmentectomy remove only a small part of the lung; consequently, they preserve almost normal breathing function after the operation.
Lobectomy. Removal of one of the lobes of the lung is called lobectomy. The patient's lung function must be adequate before undergoing this procedure. The operation carries an overall mortality rate of 3% to 5%, with older patients having the highest risk.
Pneumonectomy. Pneumonectomy removes the entire lung. The procedure itself carries a mortality rate of 5% to 8%, with the oldest patients having the greatest risk. In such patients, recurrence almost always occurs.
Other Procedures
Surgical advances are allowing a wider range of options, including minimal surgeries for early cancers and surgeries that relieve cancer symptoms in late stages of the disease.
Thoracoscopy. Thoracoscopy is a less-invasive technique that employs a thin tube containing a miniature camera and surgical instruments. It requires much smaller incisions than open surgery and speeds recovery to the point that patients are up within hours. Such procedures can have significant drawbacks, though. For instance, one such operation, the thoracoscopic wedge resection , does not allow the surgeon to fully determine the extent of lymph node involvement or the presence of metastatic disease outside of the lung's lobes. When thoracoscopy is used for a lobectomy, it may offer little advantage in reducing postsurgical pain. Thoracoscopies are also difficult to perform and are still considered experimental.
Laser Surgery. Laser surgeries allow removal of minimal amounts of lung tissue and are proving useful for improving symptoms in stage II and IIIA patients. They may also be beneficial in treating cancers that have spread to the throat, obstructing it.
Photodynamic Therapy. Photodynamic therapy uses bronchoscopy and special laser light beams combined with a photosensitive drug called porfimer sodium (Photofrin) to kill cancer cells. The most common side effect is sun sensitivity. Serious side effects include bleeding in the lungs. Photodynamic therapy may be considered for patients in early-stage disease who are not candidates for other surgical procedures. It may also be used to reduce symptoms in late-stage disease.
Cryosurgery. Cryosurgery uses a probe chilled to below freezing to destroy the tumor cells on contact and is being investigated in combination with radiation therapy. It may also be an alternative in early stage cancer for patients who cannot have surgery.
Electric Cauterization. Electric cauterization, the use of electricity to produce heat that destroys tissue, is also under investigation as a treatment for early-stage disease.
Back Surgery. Spinal cord compression is a common cause of pain in patients with advanced lung cancer. Because such patients can live for a year or longer, some research indicates that back surgery followed by radiation therapy can significantly improve the quality of life for many of these patients.
- Review Date: 6/30/2006
- Reviewed By: Harvey Simon, MD, Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital.
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