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Ulcerative colitis

Description

An in-depth report on the causes, diagnosis, treatment, and prevention of ulcerative colitis.

Alternative Names

Inflammatory bowel disease; Colitis - ulcerative

Introduction

Inflammatory bowel disease (IBD) is a general term that covers two disorders:

• Ulcerative colitis
• Crohn's disease

Some evidence suggests that they are part of a biologic continuum, but at this time they are considered distinct disorders with somewhat different treatment options. The basic distinctions are location and severity. As many as 10% of patients with IBD have findings and symptoms that match the criteria for both disorders, at least in the early stages (which is called indeterminate colitis).

Ulcerative Colitis. Ulcerative colitis occurs only in the large intestine. Ulcers form in the inner lining, or mucosa , of the colon or rectum, often resulting in diarrhea, blood, and pus. The inflammation is usually most severe in the sigmoid and rectum and usually diminishes higher in the colon. It is sometimes divided into one of four categories depending on the location of the disease:

• Proctitis. Disease only in the rectum (the lowest part of the large intestine that connects with the anus). Constitutes about 30% of cases.
• Proctosigmoiditis. Disease in the rectum and sigmoid (the next portion of the intestine leading up from the rectum). Constitutes about 30% of cases.
• Left-Sided Colitis. Disease in the left side of the large intestine. Constitutes about 40% of cases.
• Pancolitis. Disease in entire colon. Very uncommon.

In most patients the location of the disease does not change, but as many as 30% of patients with proctitis or proctosigmoiditis will experience some progression.

Crohn's Disease. Crohn's disease is an inflammation that extends into the deeper layers of the intestinal wall. It is found most often in the area bridging the small and large intestines, specifically in the ileum and the cecum, which is sometimes referred to as the ileocecal region. Crohn's disease less frequently occurs in other parts of the gastrointestinal tract, including the anus, stomach, esophagus, and even the mouth. It may affect the entire colon, form a string of contiguous ulcers in one part of the colon, or develop as multiple scattered clusters of ulcers skipping healthy tissue in between. [For more information, see In-Depth Report #103: Crohn's disease.]

The Gastrointestinal Tract The gastrointestinal (GI) tract (the digestive system) is a tube that extends from the mouth to the anus. It is a complex organ system that first carries food from the mouth down the esophagus to the stomach and then through the small and large intestine to be excreted out through the rectum and anus. Esophagus The esophagus , commonly called the food pipe, is a narrow muscular tube, about nine and a half inches long that begins below the tongue and ends at the stomach. Stomach In the stomach , acids and stomach motion break food down into particles small enough so that nutrients can be absorbed by the small intestine. Small Intestine The small intestine, despite its name, is the longest part of the gastrointestinal tract and is about 20 feet long. Food that passes from the stomach into the small intestine first passes through three parts: First it enters the duodenum Then the jejunum , and Finally the ileum . Most of the digestive process occurs in the small intestine. Large Intestine Undigested material, such as plant fiber, is passed to the large intestine , mostly in liquid form. The large intestine is approximately 6 feet long and is the final portion of the digestive tract. It follows the small intestine and includes the cecum , the appendix , the colon , and the rectum , which extends to the anus . Cecum and Appendix. The cecum and the appendix are located in the lower-right quadrant of the abdomen. Colon. The colon absorbs excess water and salts into the blood. The remaining waste matter is converted to feces through bacterial action. The colon is divided into four major sections: The first section, the ascending colon , extends upward from the cecum on the right side of the abdomen. The second section, the transverse colon , crosses the upper abdomen to the left side. The third section extends downward on the left side of the abdomen toward the pelvis and is called the descending colon . The final section is the sigmoid colon . Rectum and Anus. Feces are stored in the descending and sigmoid colon until they pass through the rectum and anus . The rectum extends through the pelvis from the end of the sigmoid colon to the anus.

• Review Date: 8/23/2006
• Reviewed By: Harvey Simon, M.D., Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital

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