Neurosurgery Clinical Research

Overview of Neurosurgical Clinical Research

At the University of Maryland Medical Center, we participate in clinical research to help develop new treatment options for future patients. This involves:

  • Coordinating research protocols from large multicenter studies and principal investigator initiated studies
  • Managing multiple grants from the National Institutes of Health (NIH), the Department of Defense (DoD) and Industry Sponsors
  • Directing several current protocols engendered from the laboratory of Dr. Marc Simard M.D., Ph.D., which are now in the clinical phase, including:
    • Innovative use of Glyburide, a drug used in the treatment of diabetes, for the treatment of traumatic brain injury and ischemic stroke
    • Conduct traumatic, acute and chronic disease studies.

Here is a list of the University of Maryland's clinical research studies:

Spinal Cord Injury

NACTN
North American Clinical Trial Network for spinal cord injury (Registry)
Principal Investigator: Bizhan Aarabi, MD
Sponsor: Christopher and Dana Reeve Foundation

RISCIS
Multi-center, randomized, placebo-controlled, double-blind trial of efficacy and safety of Riluzole in acute spinal cord injury started within 12 hours of injury
Principal Investigator: Bizhan Aarabi, MD
Sponsor: AOSpine International; Christopher and Dana Reeve Foundation; Rick Hansen Institute

Vertex
A Phase 2b/3, Double-Blind, Randomized, Placebo Controlled, Multicenter Study to Assess the Efficacy and Safety of VX-210 in Subjects With Acute Traumatic Cervical Spinal Cord Injury
Principal Investigator: Bizhan Aarabi, MD
Sponsor: Vertex Pharmaceuticals Inc.


Subarachnoid Hemorrhage (SAH) and Stroke

ASTROH
Aneurysmal Subarachnoid Hemorrhage Trial Randomizing Heparin
Principal Investigator: Francois Aldrich, MB, ChB, MMed, FCS
Sponsor: Robert F. James, MD, FAANS, FACS, Department of Neurological Surgery, University of Louisville

MISTIE III
Minimally invasive surgery plus rt-PA for intracranial hemorrhage evacuation
Principal Investigator: Francois Aldrich, MB, ChB, MMed, FCS
Sponsor: National Institutes of Health (NIH)


Movement Disorders

*To inquire about this trial at UMB, please contact Charlene Aldrich at 410-328-5332 or e-mail at [email protected]

ET002 MRgFUS  
A Pivotal Study to Evaluate the Effectiveness and Safety of ExAblate Transcranial MRgFUS Thalamotomy Treatment of Medication Refractory Essential Tremor Subjects
Principal Investigator: Howard Eisenberg, MD
Sponsor: InSightec

ET002  MRgFUS CA
A Pivotal Study to Evaluate the Effectiveness and Safety of ExAblate Transcranial MRgFUS Thalamotomy Treatment of Medication Refractory Essential Tremor Subjects
Principal Investigator: Howard Eisenberg, MD
Sponsor: InSightec

PD002 MRgFUS
A Phase I Clinical Trial of the Management of the Medically-Refractory Motor Symptoms of Advanced Idiopathic Parkinson’s Disease with Unilateral Lesioning of the Globus Pallidum Using the ExAblate Transcranial System
Principal Investigators: Howard Eisenberg, MD and Graeme Woodworth, MD
Sponsor: InSightec and FUS Foundation


Aneurysms

Newton
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study Comparing EG-1962 to Standard of Care Oral Nimodipine in Adults with Aneurysmal Subarachnoid Hemorrhage
Principal Investigator: Francois Aldrich, MB, ChB, MMed, FCS
Sponsor: Edge Therapeutics, Inc.

Intracisternal EG-1962
Multicenter, Controlled, Randomized, Safety and Pharmacokinetic Study Comparing Intracisternal EG-1962 to Standard of Care Enteral Nimodipine in Adults with Aneurysmal Subarachnoid Hemorrhage
Principal Investigator: Francois Aldrich, MB, ChB, MMed, FCS
Sponsor: Edge Therapeutics, Inc.