Peripheral Neuropathy Research and Clinical Trials

Clinical trials are studies designed to find new and better ways to treat patients with neuropathy. The physicians at the Maryland Peripheral Neuropathy Center are currently conducting the clinical trials listed below.

For more information on our studies, please contact either 

Open Trials

Improving Autonomic Function and Balance in Diabetic Neuropathy (IMABIN STUDY)

  • Investigators at the VA Maryland Health Care System and University of Maryland (Drs. James Russell and Lindsay Zilliox) are conducting a study for patients with type II diabetes or prediabetes who also have neuropathy (damage to nerves in their legs or the nerves that control heart function or blood pressure). In the Improving Autonomic Function and Balance in Diabetic Neuropathy (IMABIN Study), participants could have problems with their nerves and/or problems with their balance.  We are recruiting participants for a 1-year trial to compare two lifestyle interventions and to determine if the interventions improve neuropathy and balance.  A preliminary study has suggested that a lifestyle intervention may help patients with mild nerve disease.  Participants will be randomized into one of two groups (put into one of the two groups by the flip of a coin).  Both groups will receive an intervention to improve their lifestyle but the interventions will be different in the two groups.  The interventions focus on improving mobility, balance and nutrition.  The Participants will come to Baltimore City for part of their care. Patients will be reimbursed for the study. Some meals will be provided.  Patients will receive free testing, and nutrition and exercise counseling on nutrition, exercise, and balance as part of this trial.

    If you are interested in participating in the study and can answer yes to all the inclusion criteria below, you may be eligible for inclusion in the study. Please contact Ms. Kristin Fleishmann at 410-328-6583 or [email protected].


    Essential Screening Criteria

    Y N  
    Age 30-80 years
    Prediabetes or early controlled diabetes
    Otherwise medically stable
    Have no cause for neuropathy other than prediabetes or diabetes
    Willing to accept assignment to either intervention group

For more about the study, visit the study's page on clinicaltrials.gov.


Metabolic Syndrome and Fall Risk

The purpose of this project is to see if an exercise program can reduce fall risk in people with the metabolic syndrome (MetS) and autonomic neuropathy. The MetS is a set of risk factors for heart disease and diabetes that includes fat in the stomach area, high blood pressure, high cholesterol, and high blood sugar. The autonomic nervous system helps to control heart rate and blood pressure. Neuropathy is any disease of the peripheral nerves.

Learn more about this study on the clinicaltrials.gov page.


International Guillain-Barré Syndrome Outcome Study (IGOS)

Guillain-Barré syndrome (GBS) is a rare disorder in which the body's immune system attacks part of the peripheral nervous system. By doing this study, researchers hope to learn more about clinical and biological factors that influence the course of the disease GBS, the outcome of patients with GBS and find factors that could help diagnose GBS sooner.

Learn more about this study on the clinicaltrials.gov page.


Neuromuscular Database

Neuromuscular disorders, such as neuropathy, motor neuron disease and myopathy are common neurologic disorders that cause significant morbidity in the population. Establishing a database consisting of clinical information such as patient reported symptoms and clinician findings on physical exam facilitates further understanding of neuromuscular disorders.