Division of Pulmonary and Critical Care

Basic Research Programs

Cardiopulmonary Genomics Research:

The Cardiopulmonary Genomics Program is focused on understanding G-protein coupled receptor signaling relevant to heart and lung disease. These efforts are centered on four complementary areas: basic structure/function studies of these receptors, discovery and characterization of human mutations and polymorphisms of these genes, creation of genetically altered mice to study signal transduction or genetic variation, and human clinical studies of the relevance of genetic variation on asthma and heart failure. These studies are funded by four NIH grants.

Selected publications:

Small KM, Wagoner LE, Levin AM, Kardia SLR, Liggett SB. Synergistic polymorphisms of ₁- and _C-adrenergic receptors and the risk of congestive heart failure. New England Journal of Medicine 347:1135-1142, 2002.
Rathz DA, Gregory KN, Fang Y, Brown KM, Liggett SB. Hierarchy of polymorphic variation and desensitization permutations relative to b₁- and b₂-adrenergic receptor signaling. J Biol Chem 278:10784-10789, 2003.
McGraw DW, Almoosa KF, Paul RJ, Kobilka BK, Liggett SB. Antithetic regulation by b-adrenergic receptors of G_q-receptor signaling via phospholipase-C underlies the airway b-agonist paradox. J Clin Invest 112:619-626, 2003.
Perez JM, Rathz DA, Petrashevskaya NN, Hahn HS, Wagoner LE, Schwartz A, Dorn GW II, Liggett SB. b₁-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nature Medicine 9:1300-1305, 2003.
Mialet-Perez J, Green SA, Miller WE, Liggett SB. A primate-dominant third glycosylation site of the b₂-adrenergic receptor routes receptors to degradation during agonist regulation. J Biol Chem 279:38603-38607, 2004.
Tantisira KG, Small KM, Litonjua AA, Weiss ST, Liggett SB. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase 9 in asthma: interaction between b-agonist and corticosteroid pathways. Hum Mol Genet 14:1671-1677, 2005.

E-mail: sligg001@umaryland.edu
Website: http://medschool.umaryland.edu/liggett/home.asp

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This page was last updated on: September 14, 2009.

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