E. Goldblum, M.D.
Professor of Medicine, University of Maryland
Professor of Pathology: University of Maryland
Medicine: Infectious Disease
Medicine: Division of Pulmonary and Critical Care (secondary)
Fellowship: University of New Mexico School of Medicine
Current Research Interest:
Our laboratory is interested in the intracellular effector mechanisms that couple specific receptor-ligand interactions with opening of the pulmonary vascular endothelial paracellular pathway. More specifically, we have focused on the tyrosine phosphorylation signaling events that regulate protein-protein interactions within the zonula adherens multiprotein complex, actin organization, and cell-cell homophilic adhesion.
Our studies have included bacterial constituents (e.g., lipopolysaccharide or endotoxin, staphylococcal enterotoxin B) and members of a family of novel counteradhesive proteins (e.g., thrombospondin-1 and SPARC i.e., Secreted Protein Acidic and Rich in Cysteine). More recently, we have begun to study receptor and nonreceptor protein tyrosine phosphatases (PTPs) that associate with and restrain tyrosine phosphorylation of zonula adherens proteins with a focus on ZA-associated PTPs including PTPmu.
In a collaborative project with the laboratory of Dr. Alan S. Cross, we are engaged in studies of endogenous sialidases and the role of desialylation of surface structures on neutrophils and the endothelial barrier and how these events regulate neutrophil adherence to and migration across the endothelium. Most recently, we have studied the regulatory role that sialidases have on airway epithelial cell signaling and bacterial adhesion. In another collaboration with the laboratory of Dr. Alessio Fasano, we are studying the signaling events that couple stimulation by either the prokaryotic protein, zonula occludin toxin (ZOT), or the eukaryotic homologue, zonulin, with tight junction disassembly.
Current Research Funding:
1-800-373-4111 (physicians only)
1-800-492-5538 (patients only)
1-410-328-8919 (news media only)