Division of Pulmonary and Critical Care

Faculty Members

Stephen Ligget, M.D.
Professor of Medicine and Physiology
Director, Cardiopulmonary Genomics

Department: Division
Medicine: Pulmonary and Critical Care Medicine

Special Interests: Asthma
Medical Degree: University of Miami (1982)
Residency: Barnes Hospital and Washington University
School of Medicine, St. Louis, MO (1982-1985)
Fellowship: Pulmonary Diseases and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO Laboratory of Philip Cryer (1985-1988);
Research Fellow, laboratory of Robert J. Lefkowitz, Howard Hughes Medical Institute and Duke University Medical Center, Durham, NC (1988-1990)
Certification: Internal Medicine; Pulmonary Diseases; Critical Care Medicine (eligible)

Biography:

Assistant Professor of Medicine and Pharmacology, Duke University School of Medicine (1990-1992)
Associate Professor of Medicine, Pharmacology and Cell Biophysics, and Molecular Genetics & Biochemistry, University of Cincinnati College of Medicine (1992-1995)
Director, Division of Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine (1992-2003
Professor of Medicine, Pharmacology and Cell Biophysics, and Molecular Genetics & Biochemistry, University of Cincinnati College of Medicine (1995-2005)
Director, Cardiopulmonary Research Center, University of Cincinnati College of Medicine (1995-2005)
Professor of Medicine, Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine (2005-present)

Research Interest: Doctor Liggett is an internationally recognized leader in the field of G-protein coupled receptor biology, congestive heart failure, and asthma. He has not only made seminal discoveries in this field, but he has also recognized as one of the forces that has moved the field forward. He uses a bedside-to-bench-to-bedside approach in which polymorphisms (variations in sequence) in genes for adrenergic receptors contributes to pathogenesis and response to therapy in asthma and heart failure. Human genes encoding various polymorphisms are studied functionally in cell culture and transgenic mouse models and the findings are returned to the clinical arena to analyze the influence of these polymorphisms on disease pathogenesis and therapeutic responses in humans.

Current Research Funding:

Title:	Molecular Properties of ϖ-adrenergic Receptors in Asthma
Agency:	NIH RO1 HL45967
PI:	S. Liggett
Award Period:	3/15/02 – 2/28/12 (MERIT extended to 10 years)
Total Award:	$2,677,500

Title:	Basis of Variability of Lung GPCR Signaling
Agency:	NIH R01 HL071609
PI:	S. Liggett
Award Period:	07/01/03 – 06/30/08
Total Award:	$1,918,750

Title:	Project 2: Mechanisms of ϖ-receptor Dysfunction in Heart Failure
Agency:	NIH PO1 HL22619 (Molecular Mechanism of Contraction)
PI:	S. Liggett (Project 2), A. Schwartz (Program PI)
Award Period:	07/01/99 – 06/30/05 (renewed for 5 years)
Total Award:	$1,765,500

Title:	β2-adrenergic Pharmacogenetics Project
Agency:	NIH UO1 HL65899 (Pharmacogenetics of Asthma Treatment)
PI:	S. Liggett (ϖ↵! project), S. Weiss & S. Liggett (Program Co-PI)
Award Period:	04/01/00 – 03/31/05 (renewed for 5 years)
Total Award:	$1,856,170

Education:

M.D. - University of Miami (1982)
House Staff Training: Washington University (1982-85)
Fellowship Training (if applicable): Pulmonary and Critical Care, Washington University (1985-88) and Duke University (1988-1990)

Contact Information:
1-800-373-4111 (physicians only)
1-800-492-5538 (patients only)
1-410-328-8919 (news media only)

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This page was last updated on: October 10, 2007.

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