Microsoft PowerPoint Presentation

2/25/2004

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Table of Contents

Diabetes is Autoimmune in Etiology

How Good is Standard of Care?

Portal Venous Drainage

Effect on Secondary Complications

Effect on Secondary Complications

Effect on Secondary Complications

Effect on Secondary Complications

Kaplan Meier Patient Survival RatesCadaveric Transplants, 1995 - 2000

Kaplan Meier Patient Survival RatesWaiting List Patients, 1995 - 2000

Exclusions from Harlan Analysis

Mortality of Type 1 DiabetesEffect of Renal Dysfunction

Waiting List: Are they the same as transplanted patients?

Multivariate Mortality Analysis for PTA

Multivariate Mortality Analysis for PAK

Islet Transplantation

Islet Transplantation

Islet Transplantation for Type 1 Diabetes

GMPGood Manufacturing Practice

Pancreaticoduodenal Graft with Spleen

Dissection and Cannulation

Collagenase Distention

Pancreas Dispersal

Prepared Whole Pancreaticoduodenal Allograft

Human Islet Isolation #2

Viability Testing: Flourescein Diacetate/Propidium Iodide

5FR Catheter for Portal Vein Cannulation

Intra Portal Islet Infusion

Total Pancreatectomy and Autologous Islet Transplant: Daily Blood Glucose Range and Amount of Insulin

OGTTs Pre and 3 Months Post Total Pancreatectomy and Islet Autotransplant: C-peptide

Alloislet #1: C-Peptide after 75 gm OGTT 1 and 4 Weeks after 1st and 1 and 4 Weeks after 2nd Infusion

Daily Blood Glucose Levels Pre and 10-15 Days Post-Islet Transplantation

StrategiesAttention to detail, every step

Achieving Sufficient Islet Mass for Type 1 Diabetes

Recovery of Beta Cells

Recurrent Autoimmunity in Islet Transplant

Recurrent Autoimmunity in Islet Transplants

Pancreas or Islets?

Pancreas or Islets?

Non-Parametric Data

Author: alan and lisa