PPT Slide

Islet-transplant

Daclizumab

T-cell depletion

Sirolimus

Anti-cytokine mAb

Refined peritransplant management (insulin, heparin), culture, iodixanol gradients

trough levels 10-15 ng/ml

trough levels 7-10

Tacrolimus

Mycophenolate

trough levels 4 - 6 ng/ml

trough levels 3-5

Protocol Modifications Single Donor

14/18 insulin free with 1:1