Single donor
First protocol to consistently achieve insulin independence after single donor islet transplantation in type 1 diabetes
Islet mass 5,900 to 8,700 IE/kg
Not clear which of strategies is most important
1:1 in 75% of cases with Edmonton Protocol at this center in also suggests phenomenal potency of islet preparations
Extends impact of the Edmonton trial and marks a second critical accomplishment in the transition of islet transplants from an investigational procedure to practice of medicine
Maintenance MMF and sirolimus is sufficiently potent, provided potent induction immunosuppression is given and adequate sirolimus levels are achieved and maintained