Cerebral arteriovenous malformation
A cerebral arteriovenous malformation (AVM) is an abnormal connection between the arteries and veins in the brain that usually forms before birth.
AVM - cerebral; Arteriovenous hemangioma; Stroke - AVM; Hemorrhagic stroke - AVM
The cause of cerebral AVM is unknown. An AVM occurs when arteries in the brain connect directly to nearby veins without having the normal small vessels (capillaries) between them.
AVMs vary in size and location in the brain.
An AVM rupture occurs because of pressure and damage to the blood vessel. This allows blood to leak (hemorrhage) into the brain or surrounding tissues and reduces blood flow to the brain.
Cerebral AVMs are rare. Although the condition is present at birth, symptoms may occur at any age. Ruptures happen most often in people ages 15 to 20. It can also occur later in life. Some people with an AVM also have brain aneurysms.
In about half of people with AVMs, the first symptoms are those of a stroke caused by bleeding in the brain.
Symptoms of an AVM that is bleeding are:
Symptoms due to pressure on one area of the brain include:
Exams and Tests
Your health care provider will perform a physical examination. You'll be asked about your symptoms, with a focus on your nervous system problems. Tests that may be used to diagnose an AVM include:
Finding the best treatment for an AVM that is found on an imaging test, but is not causing any symptoms, can be difficult. Your provider will discuss with you:
- The risk that your AVM will break open (rupture). If this happens, there may be permanent brain damage.
- The risk of any brain damage if you have one of the surgeries listed below.
Your provider may discuss different factors that may increase your risk of bleeding, including:
- Current or planned pregnancies
- What the AVM looks like on imaging tests
- Size of the AVM
- Your age
- Your symptoms
A bleeding AVM is a medical emergency. The goal of treatment is to prevent further complications by controlling the bleeding and seizures and, if possible, removing the AVM.
Three surgical treatments are available. Some treatments are used together.
Open brain surgery removes the abnormal connection. The surgery is done through an opening made in the skull.
Embolization (endovascular treatment):
- A catheter is guided through a small cut in your groin. It enters an artery and then into the small blood vessels in your brain where the aneurysm is located.
- A glue-like substance is injected into the abnormal vessels. This stops the blood flow in the AVM and reduces the risk of bleeding. This may be the first choice for some kinds of AVMs, or if surgery can't be done.
- Radiation is aimed directly on the area of the AVM. This causes scarring and shrinkage of the AVM and reduces the risk of bleeding.
- It is particularly useful for small AVMs deep in the brain that are difficult to remove by surgery.
Medicines to stop seizures are prescribed if needed.
Some people, whose first symptom is excessive brain bleeding, will die. Others may have permanent seizures and brain and nervous system problems. AVMs that do not cause symptoms by the time people reach their late 40s or early 50s are more likely to remain stable, and in rare cases, cause symptoms.
Complications may include:
- Brain damage
- Intracerebral hemorrhage
- Language difficulties
- Numbness of any part of the face or body
- Persistent headache
- Subarachnoid hemorrhage
- Vision changes
- Water on the brain (hydrocephalus)
- Weakness in part of the body
Possible complications of open brain surgery include:
- Brain swelling
When to Contact a Medical Professional
Go to the emergency room or call the local emergency number (such as 911) if you have:
- Numbness in parts of the body
- Severe headache
- Other symptoms of a ruptured AVM
Also seek medical attention right away if you have a first-time seizure, because AVM may be the cause of seizures.
Lazzaro MA, Zaidat OO. Principles of neurointerventional therapy. In: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradley's Neurology in Clinical Practice. 7th ed. Philadelphia, PA: Elsevier; 2016:chap 56.
Ortega-Barnett J, Mohanty A, Desai SK, Patterson JT. Neurosurgery. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 20th ed. Philadelphia, PA: Elsevier; 2017:chap 67.
Spagnuolo E. Surgical management of cerebral arteriovenous malformations. In: Quinones-Hinojosa A, ed. Schmidek and Sweet's Operative Neurosurgical Techniques. 6th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 83.
- Last reviewed on 10/24/2016
- Amit M. Shelat, DO, FACP, Attending Neurologist and Assistant Professor of Clinical Neurology, SUNY Stony Brook, School of Medicine, Stony Brook, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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