Conjugated estrogens/methyltestosterone (By mouth)


Conjugated Estrogens (KON-joo-gay-ted ES-troe-jenz), Methyltestosterone (meth-il-tes-TOS-ter-one)

Treats symptoms of menopause, such as hot flashes. This medicine is a combination of hormones.

Brand Name(s)

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to estrogens or androgens (testosterone), or if you are pregnant or breastfeeding, or have any vaginal bleeding that has not been checked by a doctor. You should not use this medicine if you have severe liver disease, heart or circulation problems, a history of blood clots, or breast cancer.

How to Use This Medicine


  • Your doctor will tell you how much of this medicine to take and how often. Do not take more medicine or take it more often than your doctor tells you to.
  • Try to take your medicine at the same time each day while you are using it.

If a dose is missed:

  • If you miss a dose or forget to take your medicine, take it as soon as you can. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose.
  • Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you are taking blood thinners (Coumadin®), anisindione (Miradon®), or thyroid medicine (levothyroxine, Synthroid®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you have asthma, diabetes, epilepsy, migraine headaches, heart disease, kidney disease, liver disease, or mental depression.
  • Your doctor will need to check your progress at regular visits while you are using this medicine (usually every 6 months to 1 year). Be sure to keep all appointments.
  • If you have not had a hysterectomy (surgery to remove the uterus), ask your doctor about whether you should also take another female hormone called progesterone.
  • Large doses of this medicine taken over long periods of time may increase the risk of some kinds of cancer. Talk to your doctor about this risk.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Lightheadedness or fainting, changes in your vision
  • Lumps in your breast
  • Numbness or weakness in your arm or leg, pain in your chest or leg (calf)
  • Pain or burning when you urinate
  • Severe headache or vomiting, dizziness, slurred speech
  • Shortness of breath, coughing up blood
  • Stomach pain, swelling, or tenderness
  • Swelling in your hands, ankles, or feet
  • Vaginal bleeding of unknown cause
  • Yellow skin or eyes

If you notice these less serious side effects, talk with your doctor:

  • Joint or muscle pain
  • Mood changes, loss of interest in sex
  • Nausea, diarrhea, stomach upset, bloated feeling
  • Skin changes or unusual hair growth
  • Swollen or tender breasts

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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