Pergolide mesylate (By mouth)


Pergolide Mesylate (PER-goe-lide MES-i-late)

Treats Parkinson's disease. This medicine was withdrawn from the U.S. market in March 29, 2007, due to an increased chance of serious damage to heart valves.

Brand Name(s)

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have ever had an allergic reaction to pergolide or other ergot medicines (such as Cafergot®, Ergotrate®, DHE 45®, Methergine®, Migranal®, or Wigraine®).

How to Use This Medicine


  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • You may take your medicine with food to avoid stomach upset.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using droperidol (Inapsine®), metoclopramide (Reglan®), phenothiazines (such as Compazine®, Mellaril®, Phenergan®, Serentil®, Tacaryl®, Thorazine®, Trilafon®), or medicine to treat mental illness (such as Haldol®, Navane®, Taractan®, thiothixene).
  • Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have breathing problems or heart rhythm or heart valve problems.
  • This medicine may make you dizzy or drowsy. These effects may be either mild or severe.
  • Some people using this medicine have become so drowsy they have fallen asleep during routine daily activities. Severe drowsiness or sleepiness may come on very suddenly. These effects may also occur even after you have been using the medicine for several months.
  • Make sure you know how this medicine affects you before you drive, use machines, or do anything else that could be dangerous if you are not alert. Tell your doctor if you think this medicine is causing you to have severe drowsiness or sleepiness.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
  • Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Falling asleep during the day while you are driving, talking, eating, dressing, or doing any other routine activity.
  • Fast, pounding, or irregular heartbeat.
  • Jerky muscle movement you cannot control (often in your face, tongue, or jaw).
  • Lightheadedness or fainting.
  • Rapid weight gain.
  • Severe confusion, seeing or hearing things that are not there (hallucinations).
  • Shortness of breath, cold sweat, and bluish-colored skin.
  • Swelling in your hands, ankles, or feet.

If you notice these less serious side effects, talk with your doctor:

  • Changes in vision.
  • Headache, muscle or joint pain.
  • Nausea, constipation, or diarrhea.
  • Problems with urination.
  • Runny nose.
  • Stomach upset.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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